Regioselective C8-metalation of N-phosphine tethered adenine derivatives via C8-H activation.
نویسندگان
چکیده
Two new adenine derivatives bearing a N-methylene (1) or N-ethylene (2) tethered diphenylphosphine group have been reacted with [MIIICl2Cp*]2 (M = Ir, Rh) or [RuIIClCp*]4. The formation of Werner-type phosphine complexes [3]-[6] and upon heating their subsequent rearrangement into complexes bearing an NH,NR-NHC^PRPh2 chelate ligand in [7]Cl (M = Ir) and [8] (M = Ru) have been observed.
منابع مشابه
Correction: Regioselective C8-metalation of N-phosphine tethered adenine derivatives via C8-H activation.
Correction for 'Regioselective C8-metalation of N-phosphine tethered adenine derivatives via C8-H activation' by D. Brackemeyer et al., Dalton Trans., 2017, DOI: 10.1039/c7dt00682a.
متن کاملC-H bond functionalization under metalation-deprotonation process: regioselective direct arylation of 3-aminoimidazo[1,2-a]pyrazine.
Concerted metalation deprotonation (CMD) approach with appropriate proton shuttle precursor, base, and solvent (PivOH-K(2)CO(3)-toluene) has rendered a regioselective Pd-catalyzed C6-arylation of 3-aminoimidazo[1,2-a]pyrazine, a therapeutically relevant scaffold accessible by multicomponent reaction. The arylation of this heteroarene suffers from competing C5 and C2'-arylation reactions, while ...
متن کاملFORMATION OF H-addition radicals in adenine derivatives: part II.
The formation of H-addition radicals in monocrystals of adenosine, adenosine-HCl, adenine-HCl-1/2H2O, and adenine-2 HCl by X-irradiation has been st-died by using electron spin resonance spectroscopy at 9.5 GHz and at 35 GHz. In all crystals, both H-addition radicals at position C2 and at position C8 were observed. The coupling constants of these two H-addition radicals are different and depend...
متن کاملA general synthesis of C8-arylpurine phosphoramidites.
A general scheme for the synthesis of C8-arylpurine phosphoramidites has been developed. C8-Arylation of C8-bromo-2'-deoxyguanosine is the key step and has been achieved through the use of a Suzuki coupling. Since the coupling reaction is conducted under aqueous conditions, it is unnecessary to protect and then deprotect the hydroxyl groups, thus saving several steps and improving overall yield...
متن کاملTime-resolved resonance Raman investigation of the 2-fluorenylnitrenium ion reactions with C8 guanosine derivatives.
A nanosecond time-resolved resonance Raman (ns-TR3) spectroscopic study of the reactions of the 2-fluorenylnitrenium ion with several C8-substituted guanosine derivatives is reported. The TR3 spectra show that the 2-fluorenylnitrenium ion reacts with the C8-substituted guanosine derivatives (C8-methylguanosine and C8-bromoguanosine) to produce C8 intermediates with the methyl and bromine moieti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Dalton transactions
دوره 46 14 شماره
صفحات -
تاریخ انتشار 2017